5-Aminobenzimidazole → HCID 178487637、化合物

HRID 452065ノート

反応式

HRID 452065 の反応式
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH3:18][O:19][C:20]1[C:25]2[O:26][CH2:27][O:28][C:24]=2[CH:23]=[C:22]([CH:29]=O)[CH:21]=1.[Si](C#N)(C)(C)C.[N:37]1([C:42](N2C=CN=C2)=[O:43])C=CN=[CH:38]1>>[NH:13]1[C:12]2[CH:16]=[CH:17][C:9]([N:8]3[CH:29]([C:22]4[CH:21]=[C:20]([O:19][CH3:18])[C:25]5[O:26][CH2:27][O:28][C:24]=5[CH:23]=4)[CH2:38][NH:37][C:42]3=[O:43])=[CH:10][C:11]=2[N:15]=[CH:14]1

参加物

6

反応物 5

HCID 136235-AminobenzimidazoleHCID 220161,3-Benzodioxole-5-carboxaldehyde, 7-methoxy-HCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanideHCID 84468Trifluoroacetate

生成物 1

HCID 178487637HCID 178487637、化合物

実験手順

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 7-methoxybenzo[d][1,3]dioxole-5-carbaldehyde (0.721 g, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (0.521 mL, 3.74 mmol), di-(imidazol-1-yl)methanone (0.331 g, 2.04 mmol) as described in method 2. The product was purified by means of preparative HPLC.

後処理

  1. customThe product was purified by means of preparative HPLC

出典と根拠

ORDレコード
ord-a60c0bd07c9b4233adb9cf3e9f79c8a7
出典データセット
uspto-grants-2013_07
特許番号
US08486940B2

反応ノート

読み込み中…