Benzaldehyde → HCID 178516930, compound

HRID 452098Notes

Reaction equation

HRID 452098 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[SH:19][CH2:20][C:21](O)=[O:22].N1CCCCC1>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[C:21](=[O:22])[CH2:20][S:19][CH:11]3[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

5

Reactant 4

HCID 240BenzaldehydeHCID 1133Thioglycolic AcidHCID 8082PiperidineHCID 136235-Aminobenzimidazole

Product 1

HCID 178516930HCID 178516930, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (0.133 g, 1.0 mmol), benzaldehyde (0.306 mL, 3.0 mmol), mercapto acetic acid (0.276 g, 2.0 mmol), piperidine, according to method 9 step A. yield: 118 mg (40%), MS m/z: 296.3 (M+H)+, HPLC [A]): rt 5.72 min (96%)

Workup

  1. customThe compound was synthesized
  2. customrt 5.72 min (96%)

Sources & evidence

ORD record
ord-bf3899041ad9452a841a652d082de03e
Source dataset
uspto-grants-2013_07
Patent number
US08486940B2

Reaction notes

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