HRID452124
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID4610
1,2-Cyclohexanediamine
C6H14N2
HCID24386
Thionyl chloride
Cl2OS
HCID25953
Cesium fluoride
CsF
HCID160693
未命名化合物
HCID323593
4-bromobenzene-1,2-diamine
C6H7BrN2
HCID21983788
未命名化合物
HCID51003674
(3alpha)-6'-Methoxy-9-[(4-{[(4beta)-6'-methoxy-10,11-dihydrocinchonan-9-yl]oxy}phthalazin-1-yl)oxy]-10,11-dihydrocinchonan
C48H54N6O4
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Boc carbamate (2.17 g, 18.60 mmol), (DHQ)2PHAL (240 mg, 0.309 mmol), potassium osmate dihydrate (90 mg, 0.247 mmol), Thionyl chloride (0.439 mL, 6.024 mmol), 4-bromo-1,2-diamino benzene (130 mg, 0.697 mmol), cesium fluoride (212 mg, 1.395 mmoles) and copper iodide (20 mg, 0.104 mmoles), 1,2-diaminocyclohexane (1 mL), formamidine acetate (23 mg, 0.219 mmoles). Yield: 0.03 g (0.6%). MS m/z 375.3 (M+H)+; 1H-NMR 400 MHz, CDCl3): δ 7.94 (s, 1H); 7.67 (s, 1H); 7.52 (s, 1H); 7.15 (d, 3H); 6.96 (d, 2H); 5.34 (q, 1H); 4.77 (t, 1H); 4.27 (q, 1H); 2.40-2.38 (t, 1H); 0.88-0.80 (m, 4H); 0.64-0.63 (m, 4H); HPLC (λ=214 nm, [A]: rt 14.39 min (95%).
WORKUP
后处理
- customrt 14.39 min (95%)