反应详情

温度

80 °C

25 g (48 mmol) of the compound from Example 31A are dissolved in 800 ml of a 1:1 mixture of ethanol and ethyl acetate, and 18 g (286 mmol) of ammonium formate and 800 mg of palladium on carbon are added. The mixture is heated at 80° C. After 60 min, the mixture is allowed to cool and filtered through silica gel. The filter cake is washed with ethyl acetate, and the filtrate is concentrated to dryness under reduced pressure. This gives 27 g (98% of theory) of the desired product.

1. additionare added
2. temperatureto cool
3. filtrationfiltered through silica gel
4. washThe filter cake is washed with ethyl acetate
5. concentrationthe filtrate is concentrated to dryness under reduced pressure