反应详情

The title compound was prepared from Intermediate 2 (200 mg, 0.763 mmol) and 2-methoxyphenylacetic acid (190 mg, 1.148 mmol) in presence of EDCI.HCl (219 mg, 1.148 mmol), HOBt (175 mg, 1.148 mmol) and triethylamine (318 μl, 2.289 mmol) in dichloromethane (10 ml) as described in Example 1 for 6 h to give 206 mg of the product as a white solid; IR (KBr) 3272, 2979, 1634, 1475, 1248, 753 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.65-1.74 (m, 2H), 1.85-2.04 (m, 2H), 2.12-2.20 (m, 2H), 2.24-2.38 (m, 2H), 3.62 (q, J=14.7 Hz, 2H), 3.85 (s, 3H), 5.19 (q, J=9.3 Hz, 1H), 5.78 (d, J=8.4 Hz, 1H), 6.67 (d, J=8.7 Hz, 1H), 6.87-6.94 (m, 3H), 7.02 (d, J=8.4 Hz, 1H), 7.26-7.30 (m, 2H); ESI-MS (m/z) 372.50 (M+H)+.