反应详情

This compound was prepared from Intermediate 2 (500 mg, 1.923 mmol) and 2-nitrophenylacetic acid (348 mg, 1.923 mmol) in presence of EDCI.HCl (191 mg, 1.789 mmol), HOBt (153 mg, 1.789 mmol) and triethylamine (802 μl, 2.289 mmol) in dichloromethane (10 ml) as described in Example 1 for 6 h to give 550 mg of the product as a white solid. 1H NMR (300 MHz, CDCl3) δ 1.67-1.84 (m, 5H), 2.10-2.18 (m, 2H), 2.32-2.43 (m, 2H), 3.91 (s, 2H), 5.19-5.27 (m, 1H), 5.92-5.98 (m, 1H), 6.71 (d, J=9.3 Hz, 1H), 7.00-7.08 (m, 1H), 7.45-7.53 (m, 2H), 7.64 (d, J=7.5 Hz, 1H), 8.05 (d, J=8.9 Hz, 1H).