反应详情

The title compound was prepared from Intermediate 2 (200 mg, 0.764 mmol) and 2-naphthylacetic acid (213 mg, 1.141 mmol) in presence of EDCI.HCl (213 mg, 1.145 mmol), HOBt (176 mg, 1.145 mmol) and triethylamine (425 μl, 3.052 mmol) in dichloromethane (10 ml) as described in Example 1 to give 193 mg of the product as a white solid; IR (KBr) 3262, 2933, 1643, 1474, 1230, 816 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.63-1.77 (m, 2H), 1.84-1.92 (m, 2H), 1.95-2.02 (m, 2H), 2.16-2.36 (m, 2H), 3.82 (s, 2H), 5.24 (q, J=9.6 Hz, 1H), 5.50 (d, J=8.7 Hz, 1H), 6.65 (d, J=8.4 Hz, 1H), 7.00 (d, J=9.3 Hz, 2H), 7.39 (d, J=8.4 Hz, 1H), 7.45-7.50 (m, 2H), 7.73 (s, 1H), 7.78-7.86 (m, 3H); ESI-MS (m/z) 392.58 (M+H)+.