Pyridine → HCID 15904305, compound

HRID 452358Notes

Reaction equation

HRID 452358 reaction equation
O[CH2:2][C-:3]1[CH:7]=[CH:6][CH:5]=[CH:4]1.[C-:8]1([CH2:13]O)[CH:12]=[CH:11][CH:10]=[CH:9]1.[Fe+2:15].N1C=CC=CC=1.P(Cl)(Cl)[Cl:23]>C1COCC1>[Cl:23][CH2:2][C-:3]1[CH:7]=[CH:6][CH:5]=[CH:4]1.[C-:8]1([CH2:13][Cl:23])[CH:12]=[CH:11][CH:10]=[CH:9]1.[Fe+2:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24387Phosphorus trichlorideHCID 15423363HCID 15423363, compound

Product 1

HCID 15904305HCID 15904305, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a flask containing 1,1′-bis(hydroxymethyl)ferrocene (0.5 g, 2.0 mmol) under an atmosphere of nitrogen, was added THF (30 mL) and pyridine (0.33 mL, 4.1 mmol). PCl3 (0.35 mL, 4.1 mmol) was added dropwise to this solution and a yellow precipitate immediately formed. The mixture was stirred at room temperature for 3 hours. The yellow solution was decanted from the solid using a syringe and the remaining solid was washed with THF (2×15 mL). The washings and original solution were combined and evaporated to dryness. The resulting residue was used immediately in subsequent reactions.

Workup

  1. customa yellow precipitate immediately formed
  2. customThe yellow solution was decanted from the solid
  3. washthe remaining solid was washed with THF (2×15 mL)
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-1522de60e6444066a6f9c8114b666406
Source dataset
uspto-grants-2013_07
Patent number
US08492048B2

Reaction notes

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