Diethylamine → N-Ethyl-N-{[5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxin-2-YL]methyl}ethanamine

HRID 452431Notes

Reaction equation

HRID 452431 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH2:18]([NH:20][CH2:21][CH3:22])[CH3:19]>CCO>[CH2:18]([N:20]([CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1)[CH2:21][CH3:22])[CH3:19]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44482446N-Ethyl-N-{[5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxin-2-YL]methyl}ethanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (7 mg, 0.021 mmol), N-ethylethanamine (0.5 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 317 (M+, 0.3), 95 (4), 87 (6), 86 (bp), 75 (4), 58 (7).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-c2d9f8a0a8664e42892fe2281639b4b6
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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