Ethyl Acetate → HCID 17984208, compound

HRID 452529Notes

Reaction equation

HRID 452529 reaction equation
C([O:3][C:4](=[O:18])[CH2:5][CH2:6][N:7]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]=[CH:8]1)C.[OH-].[Na+].CCOC(C)=O>C(O)C>[C:12]1([C:10]2[N:9]=[CH:8][N:7]([CH2:6][CH2:5][C:4]([OH:18])=[O:3])[CH:11]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 69036029HCID 69036029, compound

Product 1

HCID 17984208HCID 17984208, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

3-(4-phenylimidazol-1-yl)propionic acid ethyl ester (2.442 g, 10 mmol) was dissolved in 50 mL of ethanol, added with 0.5N-NaOH (20 mL) and then stirred at room temperature. Initiation and termination of the reaction was confirmed with TLC (EtOAc). Upon completion of the reaction, ethanol was removed by distillation under reduced pressure to obtain the target compound.

Workup

  1. customwas removed by distillation under reduced pressure
  2. customto obtain the target compound

Sources & evidence

ORD record
ord-0d9fcb685f3b451dba5ef9964c64dcf3
Source dataset
uspto-grants-2013_07
Patent number
US08492384B2

Reaction notes

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