Hydrochloric Acid → HCID 64394799, compound

HRID 452619Notes

Reaction equation

HRID 452619 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH:20]=[CH:21][N:22]=2)[C:15]([O:17]CC)=[O:16])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].C(O)C.Cl>O1CCCC1>[C:1]1([CH2:7][CH2:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH:20]=[CH:21][N:22]=2)[C:15]([OH:17])=[O:16])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 68663927HCID 68663927, compound

Product 1

HCID 64394799HCID 64394799, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of ethyl 2-[(3-phenylpropanoyl)amino]isonicotinate (3.41 g, 11.43 mmol), 1 M aqueous sodium hydroxide solution (15 mL), ethanol (20 mL) and tetrahydrofuran (20 mL) was stirred at room temperature for 1 hr. The reaction mixture was neutralized with hydrochloric acid, and the precipitate was collected by filtration and washed with water to give the title compound (3.09 g, yield 100%) as colorless crystals.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-e345b6e8a66349f2880b9a330d335960
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

Loading…