1-(1H-Imidazol-1-yl)ethanone → HCID 68663434, compound

HRID 452662Notes

Reaction equation

HRID 452662 reaction equation
[C:1](N1C=CN=C1)(=[O:3])[CH3:2].[F:9][C:10]([F:32])([F:31])[O:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[C:22]3[CH:23]=[C:24]([C:27]([NH:29][NH2:30])=[O:28])[CH:25]=[CH:26][C:21]=3[N:20]=[CH:19]2)=[CH:14][CH:13]=1>O1CCCC1>[C:1]([NH:30][NH:29][C:27]([C:24]1[CH:25]=[CH:26][C:21]2[N:20]=[CH:19][N:18]([C:15]3[CH:14]=[CH:13][C:12]([O:11][C:10]([F:9])([F:31])[F:32])=[CH:17][CH:16]=3)[C:22]=2[CH:23]=1)=[O:28])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 68664363HCID 68664363, compound

Product 1

HCID 68663434HCID 68663434, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-acetylimidazole (264 mg, 2.4 mmol), 1-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole-6-carbohydrazide (672 mg, 2.0 mmol) and tetrahydrofuran (20 mL) was stirred overnight at room temperature, and at 50° C. for 4 hr. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the residue, and the precipitate was collected by filtration to give the title compound (614 mg, yield 81%) as colorless crystals.

Workup

  1. waitat 50° C. for 4 hr
  2. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate
  3. additionwas added to the residue
  4. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-c981ac61fb3d47fbb722ce111117a678
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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