Dimethylformamide → HCID 68663951, compound

HRID 452801Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[C:15]3[CH:16]=[C:17]([C:20]4[O:24][C:23]([NH2:25])=[N:22][N:21]=4)[CH:18]=[CH:19][C:14]=3[O:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9].CN(C)C=[O:29]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[C:15]3[CH:16]=[C:17]([C:20]4[O:24][C:23]([NH2:25])=[N:22][N:21]=4)[CH:18]=[CH:19][C:14]=3[O:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])(=[O:29])=[O:9]

Participants

Reactant 2

HCID 6228Dimethylformamide

HCID 68663978HCID 68663978, compound

Product 1

HCID 68663951HCID 68663951, compoundYield 84%

Procedure

In the same manner as in Example 140 and using 5-[3-[3-chloro-4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-amine instead of 2-methyl-5-[3-[4-(methylthio)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole and using N,N-dimethylformamide instead of dichloromethane, the title compound (yield 84%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-2b18ccceb5d54da1800fd1601deb7359
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

Loading…