1,1'-Carbonyldiimidazole → HCID 131730725, compound

HRID 452884Notes

Reaction equation

HRID 452884 reaction equation
N12CCC(CC1)[C@@H]([OH:9])C2.[C:10]([N:17]1C=CN=C1)([N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1)=[O:11]>ClCCl>[C:10](=[O:11])([O-:9])[NH2:17].[N-:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 914043-Quinuclidinol, (-)-

Product 1

HCID 131730725HCID 131730725, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction of (R)-3-Quinuclidinol with carbonyldiimidazole (CDI) in dichloromethane, at 0° C. during 4 h, afford the corresponding imidazolide carbamate (intermediate 2).

Sources & evidence

ORD record
ord-7638632b5d60435fa57e99388de317c4
Source dataset
uspto-grants-2013_07
Patent number
US08492402B2

Reaction notes

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