反应详情

To a 100 mL flask, 1-(3,5-dichloropyridin-2-yl)-3-methyl-1H-pyrazole-5-carboxylic acid (0.37 g, 1.38 mmol), dichloromethane (10 mL) and oxalyl dichloride (0.35 g, 2.20 mmol) were added. After a drop of N,N-dimethyl formamide was added, a large number of gas was released. After being stirred for overnight at room temperature, the reaction mixture was concentrated under reduced pressure. Then 10 mL toluene was added, and the mixture was concentrated again under reduced pressure to give the product (0.40 g) as yellow oil in 100% yield.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. additionThen 10 mL toluene was added
3. concentrationthe mixture was concentrated again under reduced pressure