反应详情

温度

80 °C

To a solution of 4-chloro-2-hydroxybenzamide (0.608 g, 3.54 mmol) in acetonitrile (50 ml) was added dried K2CO3 (1.71 g, 12.40 mmol) followed by benzyl bromide (0.63 ml, 5.32 mmol) and the resulting reaction mixture was refluxed at 80° C. for 16 h. After the completion of the reaction (TLC monitoring), water was added followed by extraction with EtOAc (3×100 ml). The combined organics was dried over anhydrous Na2SO4, filtered and concentrated. The residue was washed repeatedly with hexane to get rid of the excess of benzyl bromide resulting the desired product (0.75 g, 81%).

1. customthe resulting reaction mixture
2. additionwas added
3. extractionfollowed by extraction with EtOAc (3×100 ml)
4. dry with materialThe combined organics was dried over anhydrous Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. washThe residue was washed repeatedly with hexane