反应详情

温度

79 °C

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester (0.25 g, 1.024 mmol) is dissolved in AcOH (7.31 mL) and NCS (0.205 g, 1.53 mmol) is added and the reaction is heated to 79° C. for 2 hours. The reaction is cooled to room temperature and diluted with water and ethyl acetate. The organic layer is washed with 500 mL of water to remove the acid. The organic layer is dried (sodium sulfate) and concentrated to an oil (352 mg) to obtain the title compound that is used without further purification. MS (ESI) m/z 279.00 (M+1).

1. temperatureThe reaction is cooled to room temperature
2. washThe organic layer is washed with 500 mL of water
3. customto remove the acid
4. dry with materialThe organic layer is dried (sodium sulfate)
5. concentrationconcentrated to an oil (352 mg)