HCID 86667286, compound → HCID 86667285, compound

HRID 453324Notes

Reaction equation

HRID 453324 reaction equation
[CH3:1][O:2][C:3](=[O:29])/[CH:4]=[CH:5]/[C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH:12]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][CH:14]=2)[N:7]=1>C1COCC1.CO.[Pt]>[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH2:5][C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH:12]([O:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=2)[C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][CH:14]=2)[N:7]=1

Participants

5

Reactant 1

HCID 86667286HCID 86667286, compound

Product 1

HCID 86667285HCID 86667285, compound

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of unsaturated ester 6 (0.31 g, 0.65 mmol) and 5 Pt/C (0.01 g) in THF (6 mL) and MeOH (12 mL), previously purged with nitrogen, was stirred under a hydrogen atmosphere (balloon) at RT overnight. The platinum was removed by filtration through Hyflo and the filtrate was evaporated to dryness to afford the saturated ester 7, 0.31 g (99%).

Workup

  1. custompreviously purged with nitrogen
  2. customThe platinum was removed by filtration through Hyflo
  3. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-e63128a57fbe4abbaad2a3d3daf7221a
Source dataset
uspto-grants-2013_07
Patent number
US08492424B2

Reaction notes

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