Hydrochloric Acid → HCID 66634127, compound

HRID 453328Notes

Reaction equation

HRID 453328 reaction equation
[CH3:1][O:2][C:3](=[O:28])/[CH:4]=[CH:5]/[C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[O:20]CC2C=CC=CC=2)[N:7]=1.Cl>C(O)(=O)C.O=[Pt]=O>[CH3:1][O:2][C:3](=[O:28])[CH2:4][CH2:5][C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[OH:20])[N:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68641221HCID 68641221, compound

Product 1

HCID 66634127HCID 66634127, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

A stirred solution of unsaturated ester 14, (1.2 g, 2.9 mmol) and PtO2, 0.12 g in acetic acid (25 mL) and conc. HCl (5 mL) was hydrogenated at room temperature for 16 hours. The catalyst was removed by filtration through Hyflo and the filtrate was evaporated to dryness to afford the saturated ester 15, 0.8 g (90%).

Workup

  1. customThe catalyst was removed by filtration through Hyflo
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-bd38d8070ddf43bbadb11af46d367d3a
Source dataset
uspto-grants-2013_07
Patent number
US08492424B2

Reaction notes

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