Trifluoroacetic acid → HCID 59403217, compound

HRID 453560Notes

Reaction equation

HRID 453560 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[C:32]([Cl:36])[C:3]=1[CH2:4][CH2:5][NH:6][C:7]([C:9]1[CH:31]=[CH:30][C:12]([O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23]CCCC)=[O:22])=[CH:16][C:15]=2[C:28]#[N:29])=[CH:11][CH:10]=1)=[O:8].C(O)(C(F)(F)F)=O>ClCCl>[C:28]([C:15]1[CH:16]=[C:17]([CH2:20][C:21]([OH:23])=[O:22])[CH:18]=[CH:19][C:14]=1[O:13][C:12]1[CH:30]=[CH:31][C:9]([C:7](=[O:8])[NH:6][CH2:5][CH2:4][C:3]2[C:2]([Cl:1])=[CH:35][CH:34]=[CH:33][C:32]=2[Cl:36])=[CH:10][CH:11]=1)#[N:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86669064HCID 86669064, compound

Product 1

HCID 59403217HCID 59403217, compoundYield 111.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tent-Butyl 2-(4-(4-((2,6-dichlorophenethyl)carbamoyl)phenoxy)-3-cyanophenyl)acetate (34 mg, 0.065 mmol) was dissolved in dichloromethane (1 ml) and TFA (1 ml) was added. After stirring for 45 minutes, the mixture was concentrated under reduced pressure to give 2-(3-cyano-4-(4-(2,6-dichlorophenethylcarbamoyl)phenoxy)phenyl)acetic acid (0.034 g).

Workup

  1. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-da939b7fd26d4376936e8e99e013f185
Source dataset
uspto-grants-2013_07
Patent number
US08492437B2

Reaction notes

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