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HRID454022

反应详情

EQUATION

反应方程式

HRID 454022 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1
HCID11733854

tert-Butyl 4-{[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-6-methoxy-4-oxo-3,4-dihydroquinazolin-7-yl)oxy]methyl}piperidine-1-carboxylate

C26H37N3O7

PRODUCTS

生成物

1
结构：COc1cc2c(=O)n(COC(=O)C(C)(C)C)cnc2cc1OCC1CCNCC1.Cl
HCID22030672

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 6-methoxy-3-((pivaloyloxy)methyl)-7-((1-tert-butyloxycarbonylpiperidin-4-yl)methoxy)-3,4-dihydroquinazolin-4-one (7.9 g, 16 mmol) in methylene chloride (80 ml) containing 5.5M hydrogen chloride in isopropanol (80 ml) was stirred for 1 hour at ambient temperature. Ether was added and the solid was collected by filtration, washed with ether and dried under vacuum at 60° C. to give 6-methoxy-7-((piperidin-4-yl)methoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one hydrochloride (6.9 g, 100%).

WORKUP

后处理

  1. filtrationthe solid was collected by filtration
  2. washwashed with ether
  3. customdried under vacuum at 60° C.