反应详情

温度

95 °C

A mixture of 7-benzyloxy-4-chloro-6-methoxyquinazoline (3 g, 10 mmol), (prepared as described for the starting material in Example 1), 5-hydroxyindole (1.46 g, 11 mmol) in DMF (30 ml) containing potassium carbonate (2.75 g, 20 mmol) was heated at 95° C. for 2 hours. After cooling the mixture was poured onto water (100 ml). The precipitate was filtered, washed with water and dried under vacuum at 50° C. over phosphorus pentoxide. The solid was triturated with ether, filtered, washed with ether and dried under vacuum to give 7-benzyloxy-4-(indol-5-yloxy)-6-methoxyquinazoline (3.5 g, 88%).

1. custom(prepared
2. temperatureAfter cooling the mixture
3. additionwas poured onto water (100 ml)
4. filtrationThe precipitate was filtered
5. washwashed with water
6. dry with materialdried under vacuum at 50° C. over phosphorus pentoxide
7. customThe solid was triturated with ether
8. filtrationfiltered
9. washwashed with ether
10. customdried under vacuum