反应详情

Under argon, 1,2,4-triazole (13.8 g, 200 mmol) was added to a solution of sodium ethoxide (freshly prepared from sodium (4.6 g) and ethanol (250 ml)). After complete dissolution, 3-bromopropan-1-ol (18 ml, 200 mmol) was added dropwise. The mixture was refluxed for 18 hours and the solid was filtered and washed with ethanol. The filtrate was evaporated and the residue was purified by column chromatography eluting with methylene chloride/methanol (9/1) to give 3-(1,2,4-triazol-1-yl)propan-1-ol (22.8 g, 90%).

1. additionwas added dropwise
2. temperatureThe mixture was refluxed for 18 hours
3. filtrationthe solid was filtered
4. washwashed with ethanol
5. customThe filtrate was evaporated
6. customthe residue was purified by column chromatography
7. washeluting with methylene chloride/methanol (9/1)