反应详情

2-(2-Chloroethoxy)ethanol (1.25 g, 10 mmol) was added to a mixture of morpholine (2.58 g, 30 mmol) and potassium carbonate (5.5 g, 40 mmol) in acetonitrile (50 ml). The mixture was heated at reflux for 6 hours and then stirred for 18 hours at ambient temperature. The insolubles were removed by filtration and the volatiles were removed from the filtrate by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5 followed by 90/10 and then 80/20) to give 2-(2-morpholinoethoxy)ethanol (600 mg, 34%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 6 hours
3. customThe insolubles were removed by filtration
4. customthe volatiles were removed from the filtrate by evaporation
5. customThe residue was purified by column chromatography
6. washeluting with methylene chloride/methanol (95/5