反应详情

温度

100 °C

A mixture of 4-chloro-6-methoxy-7-(3-piperidinopropoxy)quinazoline (168 mg, 0.5 mmol), (prepared as described for the starting material in Example 67), potassium carbonate (207 mg, 1.5 mmol), 3-methyl-5-hydroxyindole (88 mg, 0.6 mmol), (Can. J. Chem. 1964, 42, 514), and DMA (2.0 ml) was purged with nitrogen for 5 minutes at 25° C. This mixture was then stirred at 100° C. for 3 hours then allowed to cool to ambient temperature, was filtered and the filtrate evaporated under vacuum. The residue was purified by silica column chromatography eluting with dichloromethane/methanolic ammonia (7M) (90/10) to give 6-methoxy-4-(3-methylindol-5-yloxy)-7-(3-piperidinopropoxy)quinazoline (155 mg, 69%).

1. custom(prepared
2. customwas purged with nitrogen for 5 minutes at 25° C
3. temperatureto cool to ambient temperature
4. filtrationwas filtered
5. customthe filtrate evaporated under vacuum
6. customThe residue was purified by silica column chromatography
7. washeluting with dichloromethane/methanolic ammonia (7M) (90/10)