反应详情

A solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline (5 g, 16.6 mmol), (prepared as described for the starting material in Example 1), 5-aminoindole (2.4 g, 18.2 mmol) in isopropanol (60 ml) containing 5N hydrogen chloride in isopropanol (260 μl, 1.6 mmol) was refluxed for 90 minutes. After cooling the volatiles were removed under vacuum. The solid was triturated with isopropanol, filtered, washed with isopropanol followed by ether and dried under vacuum to give 7-benzyloxy-4-(indol-5-ylamino)-6-methoxyquinazoline hydrochloride (6.9 g, 96%).

1. temperaturewas refluxed for 90 minutes
2. temperatureAfter cooling the volatiles
3. customwere removed under vacuum
4. customThe solid was triturated with isopropanol
5. filtrationfiltered
6. washwashed with isopropanol
7. customdried under vacuum