反应详情

温度

95 °C

A solution of 4-chloro-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazoline (213 mg, 0.662 mmol), (prepared as described for the starting material in Example 10), and 4-fluoro-5-hydroxyindole (120 mg, 0.794 mmol), (prepared as described for the starting material in Example 242), in DMF (3 ml) containing potassium carbonate (137 mg, 0.994 mmol) was stirred at 95° C. for 3 hours. After cooling, the mixture was partitioned between ethyl acetate and water. The organic layer was washed with water, brine, dried (MgSO4) and evaporated. The residue was triturated in cold ether. The solid was filtered and dried under vacuum to give 4-(4-fluoroindol-5-yloxy)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline (77 mg, 26%).

1. custom(prepared
2. temperatureAfter cooling
3. customthe mixture was partitioned between ethyl acetate and water
4. washThe organic layer was washed with water, brine
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe residue was triturated in cold ether
8. filtrationThe solid was filtered
9. customdried under vacuum