反应详情

A 2 mol/L aqueous solution of sodium hydroxide (0.56 mL) was added to a solution mixture of the obtained methyl 2-(benzyloxy)-4-(1H-pyrazol-1-yl)benzoate (0.11 g) in dioxane (1.1 mL) and methanol (1.1 mL), followed by stirring at room temperature for 2 hours. Water was added to the reaction mixture. After adjusting the pH to 3 with 6 mol/L hydrochloric acid, ethyl acetate was added thereto. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Diisopropyl ether and hexane were added to the obtained residue, and the solid substance was collected by filtration to obtain 0.10 g of 2-(benzyloxy)-4-(1H-pyrazol-1-yl)benzoic acid as a white solid.

1. additionwas added
2. customThe organic layer was separated
3. washwashed with a saturated aqueous solution of sodium chloride
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe solvent was evaporated under reduced pressure
6. additionDiisopropyl ether and hexane were added to the obtained residue
7. filtrationthe solid substance was collected by filtration