HCID 136198182, compound → HCID 136198186, compound

HRID 454546Notes

Reaction equation

HRID 454546 reaction equation
[OH:1][C:2]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([O:11]C(C)(C)C)=[O:10])=[O:5]>C(Cl)Cl.FC(F)(F)C(O)=O>[OH:1][C:2]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:17]=[CH:16][C:8]=1[C:9]([OH:11])=[O:10])=[O:5]

Participants

4

Reactant 1

HCID 136198182HCID 136198182, compound

Product 1

HCID 136198186HCID 136198186, compoundYield 70.4%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution mixture of the obtained tert-butyl 2-(2-hydroxy-5-(pyridin-2-yl)benzamido)-4-phenylbenzoate (0.021 g) in methylene chloride (1 mL) and trifluoroacetic acid (0.5 mL) was stirred at room temperature for 1 hour and 10 minutes. The solvent was evaporated under reduced pressure, and water was added to the obtained residue. After adjusting the pH to 7 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected by filtration to obtain 0.013 g of 2-(2-hydroxy-5-(pyridin-2-yl)benzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and water
  2. additionwas added to the obtained residue
  3. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-879036e6febc46159e180d98e0975d72
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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