Hydrochloric Acid → HCID 58508460, compound

HRID 454563Notes

Reaction equation

HRID 454563 reaction equation
CO.[OH-].[Na+].C([O:8][C:9]1[C:33]([CH3:34])=[CH:32][CH:31]=[CH:30][C:10]=1[C:11]([NH:13][C:14]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:15]=1[C:16]([O:18]C)=[O:17])=[O:12])(=O)C.Cl>O1CCOCC1>[OH:8][C:9]1[C:33]([CH3:34])=[CH:32][CH:31]=[CH:30][C:10]=1[C:11]([NH:13][C:14]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 66990783HCID 66990783, compound

Product 1

HCID 58508460HCID 58508460, compoundYield 82.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methanol (2 mL), dioxane (4 mL), and a 2 mol/L aqueous solution of sodium hydroxide (0.77 mL) were added to the obtained methyl 2-(2-acetoxy-3-methylbenzamido)-4-phenylbenzoate (0.062 g), followed by stirring at room temperature for 7 hours. The reaction mixture was adjusted to a pH of 1.1 with 6 mol/L hydrochloric acid. The solid substance was collected by filtration to obtain 0.044 g of 2-(2-hydroxy-3-methylbenzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-910728d9e98d492e9e6f377cfa0cb0da
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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