Hydrochloric Acid → HCID 46853622, compound

HRID 454583Notes

Reaction equation

HRID 454583 reaction equation
[OH-].[Na+].C([O:6][C:7]1[CH:31]=[CH:30][C:29]([C:32]2[O:33][CH:34]=[CH:35][CH:36]=2)=[CH:28][C:8]=1[C:9]([NH:11][C:12]1[CH:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=[CH:18][C:13]=1[C:14]([O:16]C)=[O:15])=[O:10])(=O)C.Cl>O1CCOCC1>[O:33]1[CH:34]=[CH:35][CH:36]=[C:32]1[C:29]1[CH:30]=[CH:31][C:7]([OH:6])=[C:8]([CH:28]=1)[C:9]([NH:11][C:12]1[CH:21]=[C:20]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:19]=[CH:18][C:13]=1[C:14]([OH:16])=[O:15])=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66990567HCID 66990567, compound

Product 1

HCID 46853622HCID 46853622, compoundYield 87.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Dioxane (2 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.79 mL) were added to the obtained methyl 2-(2-acetoxy-5-(furan-2-yl)benzamido)-4-phenylbenzoate (0.072 g), followed by stirring at room temperature for 6 hours. The reaction mixture was adjusted to a pH of 1.5 with 2 mol/L hydrochloric acid, and the solid substance was collected by filtration to obtain 0.055 g of 2-(5-(furan-2-yl)-2-hydroxybenzamido)-4-phenylbenzoic acid as a yellow solid.

Workup

  1. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-587da386385546f1a27a4d71d5d56bb7
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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