1,4-Dioxane hydrochloride → HCID 66990896, compound

HRID 454629Notes

Reaction equation

HRID 454629 reaction equation
[ClH:1].O1CCOCC1.[OH:8][C:9]1[CH:10]=[C:11]([CH:26]=[CH:27][C:28]=1[C:29](=[O:47])[NH:30][C:31]1[CH:36]=[C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:34]=[CH:33][C:32]=1[C:43]([O:45][CH3:46])=[O:44])[O:12][CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1>C(OCC)(=O)C>[ClH:1].[OH:8][C:9]1[CH:10]=[C:11]([O:12][CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[CH:26]=[CH:27][C:28]=1[C:29]([NH:30][C:31]1[CH:36]=[C:35]([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:34]=[CH:33][C:32]=1[C:43]([O:45][CH3:46])=[O:44])=[O:47]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58508535HCID 58508535, compound

Product 1

HCID 66990896HCID 66990896, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Ethyl acetate (1 mL) and a 4 mol/L hydrogen chloride-dioxane solution (0.50 mL) were added to the obtained tert-butyl 4-(3-hydroxy-4-(2-(methoxycarbonyl)-5-phenylphenylcarbamoyl)phenoxy)piperidine-1-carboxylate (0.025 g), followed by stirring at room temperature for 3 hours. The solid substance was collected from the reaction mixture by filtration to obtain 0.018 g of methyl 2-(2-hydroxy-4-(piperidin-4-yloxy)benzamido)-4-phenylbenzoate hydrochloride as a white solid.

Workup

  1. filtrationThe solid substance was collected from the reaction mixture by filtration

Sources & evidence

ORD record
ord-39d006b5f215435b837fca4163fcbe9b
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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