Methanesulfonic Acid → HCID 86659240, compound

HRID 454662Notes

Reaction equation

HRID 454662 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].O1CCCC1.[CH2:11]([N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][O:21][C:22]2[CH:23]=[CH:24][C:25]([OH:46])=[C:26]([CH:45]=2)[C:27]([NH:29][C:30]2[CH:38]=[C:37]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:36]=[CH:35][C:31]=2[C:32]([OH:34])=[O:33])=[O:28])[CH2:15][CH2:14]1)[CH3:12]>C(O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:11]([N:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][O:21][C:22]2[CH:23]=[CH:24][C:25]([OH:46])=[C:26]([CH:45]=2)[C:27]([NH:29][C:30]2[CH:38]=[C:37]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:36]=[CH:35][C:31]=2[C:32]([OH:34])=[O:33])=[O:28])[CH2:17][CH2:18]1)[CH3:12]

Participants

5

Reactant 3

HCID 6395Methanesulfonic AcidHCID 8028TetrahydrofuranHCID 58508938HCID 58508938, compound

Product 1

HCID 86659240HCID 86659240, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methanesulfonic acid (0.027 mL), tetrahydrofuran (3.0 mL), and activated carbon (0.020 g) were added to an ethanol (2.0 mL) suspension of the obtained 2-(5-(2-(4-ethylpiperazin-1-yl)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid (0.10 g), followed by stirring at room temperature for 30 minutes. The insoluble substance was removed by filtration, and the solvent was evaporated under reduced pressure. Acetone was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.090 g of 2-(5-(2-(4-ethylpiperazin-1-yl)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid dimethanesulfonate as a white solid.

Workup

  1. customThe insoluble substance was removed by filtration
  2. customthe solvent was evaporated under reduced pressure
  3. additionAcetone was added to the obtained residue
  4. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-74951d028ac145a49eaec39178c302af
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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