Methanesulfonic Acid → 2-(5-(2-(Diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid methanesulfonate

HRID 454666Notes

Reaction equation

HRID 454666 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([N:8]([CH2:37][CH3:38])[CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([OH:36])=[C:16]([CH:35]=1)[C:17]([NH:19][C:20]1[CH:28]=[C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:26]=[CH:25][C:21]=1[C:22]([OH:24])=[O:23])=[O:18])[CH3:7]>C(O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:37]([N:8]([CH2:6][CH3:7])[CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([OH:36])=[C:16]([CH:35]=1)[C:17]([NH:19][C:20]1[CH:28]=[C:27]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:26]=[CH:25][C:21]=1[C:22]([OH:24])=[O:23])=[O:18])[CH3:38]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 585088152-(5-(2-(Diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid

Product 1

HCID 866592412-(5-(2-(Diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid methanesulfonate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (3.0 mL) and methanesulfonic acid (0.011 mL) were added to the obtained 2-(5-(2-(diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid (0.079 g), followed by stirring at room temperature for 1 hour and 30 minutes. The solid substance was collected from the reaction mixture by filtration to obtain 0.049 g of 2-(5-(2-(diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid methanesulfonate as a white solid.

Workup

  1. filtrationThe solid substance was collected from the reaction mixture by filtration

Sources & evidence

ORD record
ord-6570f6aa9a7a48549a2164cf95440d39
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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