Trifluoroacetic acid → HCID 58508674, compound

HRID 454683Notes

Reaction equation

HRID 454683 reaction equation
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:37]=[CH:36][C:35]([N:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)=[CH:34][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[OH:8][C:9]1[CH:37]=[CH:36][C:35]([N:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)=[CH:34][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([O:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58508891HCID 58508891, compound

Product 1

HCID 58508674HCID 58508674, compoundYield 89.4%

Procedure

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-phenoxybenzoate (0.067 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and water and 2-propanol were added to the residue. After adjusting the pH to 6.0 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected by filtration to obtain 0.053 g of 2-(2-hydroxy-5-(piperidin-1-yl)benzamido)-4-phenoxybenzoic acid as a light yellow solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and water and 2-propanol
  2. additionwere added to the residue
  3. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-714f1d4c95ac4b2697e3675237c4e9c8
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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