Trifluoroacetic acid → HCID 58508812, compound

HRID 454764Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]1([C:14]2[CH:15]=[C:16]([C:20]([NH:22][C:23]3[CH:35]=[C:34]([C:36]4[CH:40]=[CH:39][S:38][CH:37]=4)[CH:33]=[CH:32][C:24]=3[C:25]([O:27]C(C)(C)C)=[O:26])=[O:21])[CH:17]=[N:18][CH:19]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([C:14]2[CH:15]=[C:16]([C:20]([NH:22][C:23]3[CH:35]=[C:34]([C:36]4[CH:40]=[CH:39][S:38][CH:37]=4)[CH:33]=[CH:32][C:24]=3[C:25]([OH:27])=[O:26])=[O:21])[CH:17]=[N:18][CH:19]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 58508786HCID 58508786, compound

Product 1

HCID 58508812HCID 58508812, compound

Procedure

Trifluoroacetic acid (4.0 mL) was added to the obtained tert-butyl 2-(5-phenylpyridine-3-carboxamido)-4-(thiophen-3-yl)benzoate, followed by stirring at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 47 mg of 2-(5-phenylpyridine-3-carboxamido)-4-(thiophen-3-yl)benzoic acid as a white solid.

Workup

customThe solvent was evaporated under reduced pressure, and diisopropyl ether
additionwas added to the obtained residue
filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record: ord-356934623c2c4e72bbb03ea01fccb331
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492582B2

Reaction notes

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