反应详情

2,4-Dichloropyrimidine (104, 500 mg, 3.30 mmol) was dissolved in methanol (5 mL) having 2.0 M monomethylamine dissolved therein, stirred at room temperature for 3 hours. Then, the methanol solvent was removed under reduced pressure and water was added to the reaction mixture. Organic compounds were extracted with ethyl acetate and evaporated after a treatment with sodium sulfate. Purification was performed by column chromatograph to give the target compound 2-chloro-4-(N-monomethylamino)pyrimidine (106b, 128 mg, 27%) as a yellow solid.

1. dissolutiondissolved
2. customThen, the methanol solvent was removed under reduced pressure and water
3. additionwas added to the reaction mixture
4. extractionOrganic compounds were extracted with ethyl acetate
5. customevaporated after a treatment with sodium sulfate
6. customPurification