Sodium hydride → HCID 86646560, compound

HRID 454823Notes

Reaction equation

HRID 454823 reaction equation
[H-].[Na+].[Cl:3][C:4]1[N:5]=[N:6][C:7](Cl)=[CH:8][CH:9]=1.[F:11][CH2:12][CH2:13][CH2:14][OH:15]>>[F:11][CH2:12][CH2:13][CH2:14][O:15][C:7]1[N:6]=[N:5][C:4]([Cl:3])=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 673313,6-DichloropyridazineHCID 680423-Fluoro-1-propanol

Product 1

HCID 86646560HCID 86646560, compoundYield 87%

Procedure

3-(3-Fluoropropoxy)-6-chloropyridazine (108c, 557 mg, 87%) was prepared in the same manner as in Example 26 as a white solid using sodium hydride (NaH 60%, 202 mg, 5.04 mmol), 3,6-dichloropyridazine (107, 500 mg, 3.36 mmol) and 3-fluoro-1-propanol (393 mg, 5.04 mmol).

Sources & evidence

ORD record
ord-c817411a81be4171adfddef722521826
Source dataset
uspto-grants-2013_07
Patent number
US08497260B2

Reaction notes

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