1-Methylpiperazine → HCID 178480642, compound

HRID 454835Notes

Reaction equation

HRID 454835 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:27]N1CCNCC1>>[CH3:27][N:22]1[CH2:21][CH2:20][N:19]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178515211HCID 178515211, compound

Product 1

HCID 178480642HCID 178480642, compound

Procedure

The title compound was prepared following the procedure described for 6a using 1-methylpiperazine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 2.52 (3H, s), 2.84 (4H, brm), 3.62 (4H, brm), 7.11 (1H, t, J=7.22 Hz), 7.20 (1H, d, J=9.28 Hz), 7.40 (2H, dd, J=8.30, 7.57 Hz), 7.80 (1H, d, J=9.28 Hz), 8.21 (2H, d, J=7.57 Hz), 8.50 (1H, s). m/z 361.4 (MH+).

Sources & evidence

ORD record
ord-c40c15c1804a45c4b444fc9adbfb5784
Source dataset
uspto-grants-2013_07
Patent number
US08497262B2

Reaction notes

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