Hydrochloric Acid → HCID 86660173, compound

HRID 454911Notes

Reaction equation

HRID 454911 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:8]([O:13][CH:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[N:9][CH:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.[ClH:27]>CO>[ClH:27].[NH:17]1[CH2:18][CH2:19][CH:14]([O:13][C:8]2[C:7]([CH:4]3[CH2:5][CH2:6][O:1][CH2:2][CH2:3]3)=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58548116HCID 58548116, compound

Product 1

HCID 86660173HCID 86660173, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To tert-butyl 4-((3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)oxy)piperidine-1-carboxylate (3.2 g, 8.8 mmol) was added 4 M HCl in MeOH (100 mL). The solution was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give the title compound (2 g, 9.8 mmol, yield 95%). ESI-MS (M+1): 263 calc. for C15H22N2O2 262.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-8ca9bbbefce04742be92647ebedbba5d
Source dataset
uspto-grants-2013_07
Patent number
US08497265B2

Reaction notes

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