反应详情

温度

60 °C

To 34 mg (0.122 mmol) of the [(R)-2-hydroxy-1-(4-hydroxy-2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester and 2-ethylbutylbromide (20 ul, 0.182 mmol) dissolved in 1 ml DMF was added K2CO3 (34 mg, 0.244 mmol) and heated to 60° C. overnight. It was cooled to rt, diluted with ether, and quenched with water. The organic layer was washed with water and brine, and then dried over MgSO4. After removal of the solvent, the residue was purified by flash column (35% EtOAc in hexane) to give the titled compound (24 mg, 54%).

1. temperatureIt was cooled to rt
2. customquenched with water
3. washThe organic layer was washed with water and brine
4. dry with materialdried over MgSO4
5. customAfter removal of the solvent
6. customthe residue was purified by flash column (35% EtOAc in hexane)