Methylamine → HCID 67029123, compound

HRID 455074Notes

Reaction equation

HRID 455074 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([NH:24][CH2:25]C)=[N:20][C:19]2=[O:27])=[CH:4][CH:3]=1.ClC1C=CN(CC2N3C=CC=CC3=NC=2C2C=CC(Cl)=CC=2)C(=O)N=1.CN>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([NH:24][CH3:25])=[N:20][C:19]2=[O:27])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 58337018HCID 58337018, compoundHCID 67028967HCID 67028967, compound

Product 1

HCID 67029123HCID 67029123, compound

Procedure

The title compound was prepared according to the experimental for compound 132 from 4-chloro-1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2(1H)-one and methylamine. M/e− 366 for C19H17ClN5O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.42 (d, J=6.6 Hz, 1H), 7.68 (d, J=8.4 Hz, 2H), 7.62 (m, 1H), 7.46 (d, 8.4 Hz, 2H), 7.28 (d, J=7.7 Hz, 1H), 6.86 (t, J=6.9 Hz, 1H), 6.64 (d, J=7.3 Hz, 1H), 5.51 (s, 2H), 5.41 (d, J=7.3 Hz, 1H), 5.24 (bs, 1H), 2.98 (s, 3H) ppm.

Sources & evidence

ORD record
ord-fb54633c0b594d899a327e16f6a66931
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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