Sodium ethoxide → HCID 67028969, compound

HRID 455078Notes

Reaction equation

HRID 455078 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21](NCC)=[N:20][C:19]2=[O:27])=[CH:4][CH:3]=1.ClC1C=CN(CC2N3C=CC=CC3=NC=2C2C=CC(Cl)=CC=2)C(=O)N=1.[CH3:53][CH2:54][O-:55].[Na+]>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([O:55][CH2:54][CH3:53])=[N:20][C:19]2=[O:27])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 2723922Sodium ethoxideHCID 58337018HCID 58337018, compoundHCID 67028967HCID 67028967, compound

Product 1

HCID 67028969HCID 67028969, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the experimental for compound 132 from 4-chloro-1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2(1H)-one and NaOEt in EtOH. M/e+ 381 for C20H18ClN4O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.36 (d, J=7.0 Hz, 1H), 8.17 (s, 1H), 7.66 (d, J=8.4 Hz, 2H), 7.48 (d, J=8.4 Hz, 2H), 7.30 (m, 1H), 6.92 (m, 1H), 6.89 (d, J=6.9 Hz, 1H), 5.71 (d, J=6.9 Hz, 1H), 5.60 (s, 2H), 4.40 (q, J=6.9 Hz, 2H), 1.32 (t, J=6.9 Hz, 3H) ppm.

Sources & evidence

ORD record
ord-8e2aca9e82e14045b20fc27617e2b8d9
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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