Piperidine → HCID 67028821, compound

HRID 455152Notes

Reaction equation

HRID 455152 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH2:22][C:21](NCCN(C)C)=[CH:20][C:19]2=[O:29])=[CH:4][CH:3]=1.ClC1C=CC(C2N=[C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][N:40]3C=2CN2CC(OC)=CC2=O)=CC=1.N1CCCCC1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH2:22][C:21]([N:40]3[CH2:41][CH2:42][CH2:43][CH2:44][CH2:39]3)=[CH:20][C:19]2=[O:29])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 67028741HCID 67028741, compoundHCID 67029115HCID 67029115, compound

Product 1

HCID 67028821HCID 67028821, compound

Procedure

The title compound was prepared according to the experimental for compound 237 from 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-methoxy-1H-pyrrol-2(5H)-one and piperidine. (62 mg, 54%) m/e+=407 (M+H+). 1H-NMR (400 MHz, CDCl3, δ): 8.49 (d, 1H, D, J=7.0 Hz), 7.73 (d, 2H, D, J=8.4 Hz), 7.62 (d, 1H, D, J=9.2 Hz), 7.47 (d, 2H, D, J=8.4 Hz), 7.25 (t, 1H, D, J=7.3 Hz), 6.85 (t, 1H, D, J=7.3 Hz), 5.09 (s, 2H), 4.69 (s, 1H), 3.56 (s, 2H), 2.99 (m, 4H), 1.63 (m, 2H), 1.53 (m, 4H).

Sources & evidence

ORD record
ord-aa009037f50c4e029770b3815013df93
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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