1-Methylpiperazine → HCID 67028870, compound

HRID 455158Notes

Reaction equation

HRID 455158 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][C:18]2[N:23]=[CH:22][N:21]=[C:20]([NH:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])[CH:19]=2)=[CH:4][CH:3]=1.Cl[C:31]1C=CC(C2N=C3C=CC=CN3C=2CC2C=C(Cl)N=CN=2)=CC=1.CN1CCNCC1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][C:18]2[CH:19]=[C:20]([N:24]3[CH2:31][CH2:29][N:27]([CH3:28])[CH2:26][CH2:25]3)[N:21]=[CH:22][N:23]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 67308199HCID 67308199, compoundHCID 86655129HCID 86655129, compound

Product 1

HCID 67028870HCID 67028870, compound

Procedure

The title compound was prepared according to Method D and the experimental for compound 243 from 2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine and 1-methylpiperazine. (59 mg, 45%) m/e+=419 (M+H+). 1H-NMR (400 MHz, CDCl3, δ): 8.57 (s, 1H), 7.93 (d, 1H, D, J=7.0 Hz), 7.73 (d, 2H, D, J=8.4 Hz), 7.67 (d, 1H, D, J=8.8 Hz), 7.42 (d, 2H, D, J=8.8 Hz), 7.25 (t, 1H, D, J=7.7 Hz), 6.81 (t, 1H, D, 7.7 Hz), 6.05 (s, 1H), 4.39 (s, 2H), 3.48 (m, 4H), 2.37 (m, 4H), 2.28 (s, 3H).

Sources & evidence

ORD record
ord-69812b2870284e95bd678506749b7ce9
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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