反应详情

温度

60 °C

A solution of 4-chloro-N-methylbutane-1-sulfonamide (Example 5; 86.7 mmol), and sodium iodide (95.4 mmol) in DMF (175 ml) was stirred for 10 min at room temperature. Sodium cyanide (191 mmol) was added and the mixture was stirred overnight at 60° C. The mixture was filtered off and the filtrate was extracted with AcOEt/water. The crude product was concentrated and was used without further purification in the next step (Examples 10 and 20).

1. filtrationThe mixture was filtered off
2. extractionthe filtrate was extracted with AcOEt/water
3. concentrationThe crude product was concentrated
4. customwas used without further purification in the next step (Examples 10 and 20)