Lithium Hydroxide → HCID 44205943, compound

HRID 456214Notes

Reaction equation

HRID 456214 reaction equation
C([O:3][C:4](=[O:39])[CH:5]([C:7]1[CH:8]=[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH2:25][N:26]2[C@@H:30]([CH3:31])[C@@H:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[O:28][C:27]2=[O:38])[C:10]([O:13][CH3:14])=[CH:11][CH:12]=1)[CH3:6])C.[OH-].[Li+]>CO>[CH3:14][O:13][C:10]1[C:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:17][C:16]=2[CH2:25][N:26]2[C@@H:30]([CH3:31])[C@@H:29]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[O:28][C:27]2=[O:38])=[CH:8][C:7]([CH:5]([CH3:6])[C:4]([OH:39])=[O:3])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66890942HCID 66890942, compound

Product 1

HCID 44205943HCID 44205943, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

To 2-[6-methoxy-2′-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4′-trifluoromethyl-biphenyl-3-yl]-propionic acid ethyl ester (0.05 g, 0.09 mmol) in MeOH (2 mL) was added lithium hydroxide (1N; 1 mL, 1.0 mmol), and the reaction was stirred at 65° C. for 3 hours. The crude material was purified by preparative HPLC to give the title compound. M+H is 514.

Workup

  1. customThe crude material was purified by preparative HPLC

Sources & evidence

ORD record
ord-124bd86acb8045bd834e8ad57a14e95f
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Reaction notes

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