反应详情

温度

80 °C

A mixture of 1-[4-(7-trifluoromethyl-benzo[b]thiophen-3-yl)-piperidin-1-yl]-ethanone (2.95 g, 9.01 mmol), concentrated HCl (30 mL), and ethanol was heated at 80° C. for 18 h. After cooling to room temperature, the reaction was basified with 20% aqueous potassium carbonate (150 mL) and the mixture extracted with DCM (2×100 mL). The organics were washed with water (100 mL), dried over potassium carbonate, filtered, and concentrated to give 2.42 g (94%) the desired product as an amber waxy solid.

1. temperatureAfter cooling to room temperature
2. extractionthe mixture extracted with DCM (2×100 mL)
3. washThe organics were washed with water (100 mL)
4. dry with materialdried over potassium carbonate
5. filtrationfiltered
6. concentrationconcentrated