反应详情

温度

85 °C

A solution of (a) (2 g, 8.7 mmol) in water (220 ml) containing sodium hydroxide (17 mmol) was hydrogenated over 10% palladium on charcoal (1g) for 4 hours. The mixture was filtered and evaporated to give a white solid. This solid was dissolved in N,N-dimethylformamide (8 ml) then treated with potassium carbonate (2.9 g) and 1,2-dibromoethane (0.6 ml, 7 mmol). The mixture was heated at 85° C. overnight. The cooled mixture was evaporated onto silica and chromatographed eluting with 10–30% methanol in ethyl acetate affording a white solid (250 mg, 21%).

1. filtrationThe mixture was filtered
2. customevaporated
3. customto give a white solid
4. customThe cooled mixture was evaporated onto silica
5. customchromatographed
6. washeluting with 10–30% methanol in ethyl acetate affording a white solid (250 mg, 21%)