Hydrazine hydrate (1:1) → HCID 178478094, compound

HRID 456624Notes

Reaction equation

HRID 456624 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][CH:12]=[CH:13][C:14]=2[C:15]2[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:22])=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:24][NH2:25]>C(O)C>[Cl:22][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]([Cl:21])[C:15]=1[C:14]1[CH:13]=[CH:12][NH:11][C:10]=1[C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[NH:25][N:24]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436870HCID 18436870, compound

Product 1

HCID 178478094HCID 178478094, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (2-chloro-pyridin-3-yl)-[3-(2,6-dichloro-phenyl)-1H-pyrrol-2-yl]-methanone (160 mg) and hydrazine hydrate (0.5 mL) in ethanol (8 mL) was heated at 90–100° C. for 24 hours. The reaction was concentrated, the residue was purified on a silica gel column to give 30 mg of the titled compound.

Workup

  1. temperaturewas heated at 90–100° C. for 24 hours
  2. concentrationThe reaction was concentrated
  3. customthe residue was purified on a silica gel column

Sources & evidence

ORD record
ord-c2c7d35a9480407bb22f5496e0259f3d
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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